Destek E?itim Odas?nda Görevlendirilen S?n?f Ö?retmenlerinin S?n?f Yönetimine ?li?kin Bilgi Düzeyleri

SnapShot: Chromatin Remodeling:SWI/SNF

SWI/SNF complex in disorder

Heterozygous germline mutations in components of switch/sucrose nonfermenting (SWI/SNF) chromatin remodeling complexes were recently identified in patients with non-syndromic intellectual disability, Coffin-Siris syndrome and Nicolaides-Baraitser syndrome. The common denominator of the phenotype of these patients is severe intellectual disability and speech delay. Somatic and germline mutations...

SWI/SNF Infobase—An exclusive information portal for SWI/SNF remodeling complex subunits

Chromatin remodeling complexes facilitate the access of condensed genomic DNA during transcription, replication, and repair, by altering the histone-DNA contacts in the nucleosome structures. SWI/SNF (SWItch/Sucrose Non-Fermentable) family of ATP dependent chromatin remodeling complexes have been documented for their tumour suppressor function. Recent studies have reported the high frequency of...

Architecture of the SWI/SNF-nucleosome complex.

The SWI/SNF complex disrupts and mobilizes chromatin in an ATP-dependent manner. SWI/SNF interactions with nucleosomes were mapped by DNA footprinting and site-directed DNA and protein cross-linking when SWI/SNF was recruited by a transcription activator. SWI/SNF was found by DNA footprinting to contact tightly around one gyre of DNA spanning approximately 50 bp from the nucleosomal entry site ...

SNF: A Special Normal Form for ESOPs

This paper introduces a new normal form for Exclusive Sums-of-Products (ESOPs) of completely specified Boolean functions. We study the properties of the SNF and show its special place among canonical Reed-Muller representations. We propose to use the SNF in a number of applications related to the exact ESOP minimization. We describe an efficient way to compute the SNF with the complexity propor...